Product Description
中文名称：LAM抗原
货号：GOMY6200
物种来源：Mycobacterium tuberculosis H37Rv
分子量：≈37kDa
介绍：脂阿拉伯甘露聚糖（Lipoarabinomannan, LAM）是一种存在于结核分枝杆菌等病原菌细胞壁中的关键脂多糖复合物，由阿拉伯甘露聚糖（多糖链）和脂质锚定结构组成。它在细菌的免疫逃逸、致病性及宿主免疫应答调节中发挥重要作用，也是结核病诊断的重要生物标志物。
Mannosylated lipoarabinomannans are multifaceted molecules. They have been shown to exert an immunosuppressive role in the immunopathogenesis of tuberculosis. They are also described as antigens of host double negative αβ T-cells。The highly immunogenic lipoglycans ubiquitously found in the mycobacterial envelope, the lipoarabinomannans (LAMs)，are thought to play a major role in the immunopathogenesis of tuberculosis. They regulate cytokine secretion ，block the transcriptional activation of interferon-γ, and neutralize the potentially cytotoxic oxygen free radicals. Mannosylated LAMs (ManLAMs) selectively bind murine and human macrophages via the mannose receptor and have been found to stimulate CD4/CD8 double negative and CD8 αβ T cells restricted by CD1 molecules.
储存：Avoid repeated freeze-thaw cycles. 6 -12months from date of receipt at -20°C
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